A few years ago I picked up a High Standard Sentinel R-101 snubbie with a 3" barrel. It came with a square butt grip, which is very comfortable. However, HS also made round butt grips for these guns, which would make it a little easier to carry in a coat pocket. I was able to buy one from Numrich awhile ago but didn't get around to changing it out until today.
As the gun came:
And with the round butt:
Changing the grip required removing the only screw in the gun, which goes through the bottom of the grip into the grip frame.
The original grip has molded in checkering while the round grip is smooth. The gun feels secure in my hand but we'll see how it is when I'm sweating. I've also seen the round butt with checkering, which would have been ideal.
One might wonder at the point of a .22 snub. These guns were sold for use as plinkers or tackle box guns, but they are usable for defense even if they aren't ideal due to the caliber. It has a 9-shot cylinder so capacity is on par with a lot of autoloaders.
Because of the heavy double action pull I wouldn't recommend any rimfire revolver for defense if you have weak hands, but if you have hand issues that prevent being able to deal with the recoil of a .38 Special or other better caliber, it beats harsh language or a pointed stick.
The High Standard has been perfectly reliable for me so far. The hammer hits the cartridge rims with authority and as far as I can recall, I've yet to experience a misfire. I tried some Remington Yellow Jacket hypervelocity ammo and got sticky extraction, but that's the only issue I've had with it. I intend to try CCI Stingers and Federal Punch in it. (I have a box of the Punch that I'd bought for use in my Ruger LCP II Lite Rack, but it had a lot of malfunctions with it.)